SUPRATHRESHOLD ODOR INTENSITY PERCEPTION IN EARLY STAGE PARKINSON’S DISEASE
Identifieur interne : 000425 ( Main/Exploration ); précédent : 000424; suivant : 000426SUPRATHRESHOLD ODOR INTENSITY PERCEPTION IN EARLY STAGE PARKINSON’S DISEASE
Auteurs : Richard L. Doty [États-Unis] ; Evan Beals [États-Unis] ; Allen Osman [États-Unis] ; Jacob Dubroff [États-Unis] ; Inna Chung [États-Unis] ; Fidias E. Leon-Sarmiento [États-Unis] ; Howard Hurtig [États-Unis] ; Gui-Shuang Ying [États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2014.
English descriptors
- KwdEn :
- Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Odors, Olfaction Disorders (etiology), Olfaction Disorders (radionuclide imaging), Olfactory Perception (physiology), Organotechnetium Compounds (diagnostic use), Parkinson Disease (complications), Parkinson Disease (radionuclide imaging), Smell (physiology), Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use).
- MESH :
- chemical , diagnostic use : Organotechnetium Compounds, Tropanes.
- complications : Parkinson Disease.
- etiology : Olfaction Disorders.
- physiology : Olfactory Perception, Smell.
- radionuclide imaging : Olfaction Disorders, Parkinson Disease.
- Aged, Cohort Studies, Female, Humans, Male, Middle Aged, Odors, Tomography, Emission-Computed, Single-Photon.
Abstract
It is unknown whether Parkinson’s disease (PD) influences suprathreshold changes in perceived odor intensity. In Alzheimer’s disease, schizophrenia, and the elderly, such perception is reportedly normal. If generally true, this could reflect a core element of the olfactory system insulated to some degree from age- and disease-related pathologies.
Odor intensity ratings for pentyl acetate were obtained from 29 early stage PD patients when on and off dopamine-related medications (DRMs) and from 29 matched controls.
The ratings were significantly attenuated at the higher odorant concentrations, with the degree of attenuation associated with overall olfactory dysfunction. Ratings were higher in the right than in the left naris of both patients and controls. No associations with DRMs, UPDRS scores, or striatal dopamine transporter activity were found.
PD influences suprathreshold estimates of perceived odor intensity, negating the notion that such perception might be spared in this disease. No association with dopaminergic processes was apparent.
Url:
DOI: 10.1002/mds.25946
PubMed: 24976213
PubMed Central: 4511086
Affiliations:
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Doty</name><affiliation wicri:level="2"><nlm:aff id="A1">Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Beals, Evan" sort="Beals, Evan" uniqKey="Beals E" first="Evan" last="Beals">Evan Beals</name><affiliation wicri:level="2"><nlm:aff id="A1">Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Osman, Allen" sort="Osman, Allen" uniqKey="Osman A" first="Allen" last="Osman">Allen Osman</name><affiliation wicri:level="2"><nlm:aff id="A1">Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Dubroff, Jacob" sort="Dubroff, Jacob" uniqKey="Dubroff J" first="Jacob" last="Dubroff">Jacob Dubroff</name><affiliation wicri:level="2"><nlm:aff id="A2">Department of Radiology, Division of Nuclear Medicine and Clinical Molecular Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Division of Nuclear Medicine and Clinical Molecular Imaging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Chung, Inna" sort="Chung, Inna" uniqKey="Chung I" first="Inna" last="Chung">Inna Chung</name><affiliation wicri:level="2"><nlm:aff id="A1">Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Leon Sarmiento, Fidias E" sort="Leon Sarmiento, Fidias E" uniqKey="Leon Sarmiento F" first="Fidias E." last="Leon-Sarmiento">Fidias E. Leon-Sarmiento</name><affiliation wicri:level="2"><nlm:aff id="A1">Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Smell and Taste Center, Department of Otorhinolaryngology: Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hurtig, Howard" sort="Hurtig, Howard" uniqKey="Hurtig H" first="Howard" last="Hurtig">Howard Hurtig</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Ying, Gui Shuang" sort="Ying, Gui Shuang" uniqKey="Ying G" first="Gui-Shuang" last="Ying">Gui-Shuang Ying</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Ophthalmology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Ophthalmology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odors</term><term>Olfaction Disorders (etiology)</term><term>Olfaction Disorders (radionuclide imaging)</term><term>Olfactory Perception (physiology)</term><term>Organotechnetium Compounds (diagnostic use)</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (radionuclide imaging)</term><term>Smell (physiology)</term><term>Tomography, Emission-Computed, Single-Photon</term><term>Tropanes (diagnostic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Organotechnetium Compounds</term><term>Tropanes</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Olfaction Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Olfactory Perception</term><term>Smell</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Olfaction Disorders</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Odors</term><term>Tomography, Emission-Computed, Single-Photon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">It is unknown whether Parkinson’s disease (PD) influences suprathreshold changes in perceived odor intensity. In Alzheimer’s disease, schizophrenia, and the elderly, such perception is reportedly normal. If generally true, this could reflect a core element of the olfactory system insulated to some degree from age- and disease-related pathologies.</p></sec><sec id="S2"><title>Methods</title><p id="P2">Odor intensity ratings for pentyl acetate were obtained from 29 early stage PD patients when on and off dopamine-related medications (DRMs) and from 29 matched controls.</p></sec><sec id="S3"><title>Results</title><p id="P3">The ratings were significantly attenuated at the higher odorant concentrations, with the degree of attenuation associated with overall olfactory dysfunction. Ratings were higher in the right than in the left naris of both patients and controls. No associations with DRMs, UPDRS scores, or striatal dopamine transporter activity were found.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">PD influences suprathreshold estimates of perceived odor intensity, negating the notion that such perception might be spared in this disease. No association with dopaminergic processes was apparent.</p></sec></div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Doty, Richard L" sort="Doty, Richard L" uniqKey="Doty R" first="Richard L." last="Doty">Richard L. Doty</name></region><name sortKey="Beals, Evan" sort="Beals, Evan" uniqKey="Beals E" first="Evan" last="Beals">Evan Beals</name><name sortKey="Chung, Inna" sort="Chung, Inna" uniqKey="Chung I" first="Inna" last="Chung">Inna Chung</name><name sortKey="Dubroff, Jacob" sort="Dubroff, Jacob" uniqKey="Dubroff J" first="Jacob" last="Dubroff">Jacob Dubroff</name><name sortKey="Hurtig, Howard" sort="Hurtig, Howard" uniqKey="Hurtig H" first="Howard" last="Hurtig">Howard Hurtig</name><name sortKey="Leon Sarmiento, Fidias E" sort="Leon Sarmiento, Fidias E" uniqKey="Leon Sarmiento F" first="Fidias E." last="Leon-Sarmiento">Fidias E. Leon-Sarmiento</name><name sortKey="Osman, Allen" sort="Osman, Allen" uniqKey="Osman A" first="Allen" last="Osman">Allen Osman</name><name sortKey="Ying, Gui Shuang" sort="Ying, Gui Shuang" uniqKey="Ying G" first="Gui-Shuang" last="Ying">Gui-Shuang Ying</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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